The PhysioDesigner 1.2 has been relased. That  is now available from  http://physiodesigner.org/

Final Plenary meeting of FY2014 has held on Mar. 4-5, 2015 at Nakanoshima-Center, Osaka University. Continuously, The Memorial Symposium has held on Mar. 6, 2015.

All principal investigators and collaborators have joined in the meeting and symposium and have discussed the productions at this project.

An important original paper by Prof. Ishikawa group was published in Circulation.

Utako Yokoyama, Susumu Minamisawa, Aki Shioda, Ryo Ishiwata, Mei-Hua Jin, Munetaka Masuda, Toshihide Asou, Yukihiko Sugimoto, Hiroki Aoki, Tomoyuki Nakamura, Yoshihiro Ishikawa.

Prostaglandin E₂ Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling.

Circulation. 2014; 129: 487-496 Published online before print October 2013, doi: 10.1161/CIRCULATIONAHA.113.004726

An important original paper by Dr. Aoki group was published by Molecular and Cellular Biology.

Wakako Sadaie, Yoshie Harada, Michiyuki Matsuda and Kazuhiro Aoki.

Quantitative In Vivo Fluorescence Cross-Correlation Analyses Highlight the Importance of Competitive Effects in the Regulation of Protein-Protein Interactions.

Published ahead of print 23 June 2014, doi:10.1128/MCB.00087-14

The PhysioDesigner 1.0 has been relased. That  is now available from  http://physiodesigner.org/

An important original paper by Prof. Makita group was published by Circulation: Cardiovascular Genetics.

Naomasa Makita, Nobue Yagihara, Lia Crotti, Christopher N. Johnson, Britt-Maria Beckmann, Michelle S. Roh, Daichi Shigemizu, Peter Lichtner, Taisuke Ishikawa, Takeshi Aiba, Tessa Homfray, Elijah R. Behr, Didier Klug, Isabelle Denjoy, Elisa Mastantuono, Daniel Theisen, Tatsuhiko Tsunoda, Wataru Satake, Tatsushi Toda, Hidewaki Nakagawa, Yukiomi Tsuji, Takeshi Tsuchiya, Hirokazu Yamamoto, Yoshihiro Miyamoto, Naoto Endo, Akinori Kimura, Kouichi Ozaki, Hideki Motomura, Kenji Suda, Toshihiro Tanaka, Peter J. Schwartz, Thomas Meitinger, Stefan Kääb, Pascale Guicheney, Wataru Shimizu, Zahurul A. Bhuiyan, Hiroshi Watanabe, Walter J. Chazin and Alfred L. George.

Novel Calmodulin (CALM2) Mutations Associated with Congenital Arrhythmia Susceptibility

Published online before print June 10, 2014, doi: 10.1161/​CIRCGENETICS.113.000459

An important original paper by Prof. Makita group was published by Circulation: Arrhythmia and Electrophysiology.

Keisuke Abe, Taku Machida, Naokata Sumitomo, Hirokazu Yamamoto, Kimie Ohkubo, Ichiro Watanabe, Takeru Makiyama, Satoki Fukae, Masaki Kohno, Daniel T. Harrell, Taisuke Ishikawa, Yukiomi Tsuji, Akihiko Nogami, Taichi Watabe, Yasushi Oginosawa, Haruhiko Abe, Koji Maemura, Hideki Motomura and Naomasa Makita

Sodium Channelopathy Underlying Familial Sick Sinus Syndrome with Early Onset and Predominantly Male Characteristics

Published online before print April 24, 2014, doi: 10.1161/​CIRCEP.113.001340

An important original paper that Prof. Makita was contributed  was published by Nature Genetics.

Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud J-B, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kaab S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bezieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Marec HL, Wilde AA, Probst V, Schott JJ, Dina C, Redon R.

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

Nature Genetics, 45,1044–1049 (2013) doi:10.1038/ng.2712

HD Physiology symposium will be held at  Knowledge Capital Congres Convention Center,  at June 14 (Sat), 2014.

Please access the official site about detailed information.

The 2nd PhysioDesigner tutorial in HD Physiology for young researchers will be held at Osaka University Nakanoshima Center at April  25, 2014.

Please access this site about detailed information.

The PhysioDesigner 1.0 RC1 has been relased. That  is now available from  http://physiodesigner.org/

An important original paper by Prof. Kurachi group was published by Journal of Physiology.

Chen IS, Furutani K, Inanobe A, Kurachi Y.

RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.

J Physiol. 2014 Mar 15;592(Pt 6):1237-48. doi: 10.1113/jphysiol.2013.269803. Epub 2014 Jan 13.

8th Plenary meeting of FY2013 will be held on March. 3-5, 2014 at Kyoto University.

All principal investigators and collaborators will join in the meeting and will discuss the research plan and management of this project.

The PhysioDesigner 1.0 beta7 has been relased. That  is now available from  http://physiodesigner.org/

Tokyo International Forum, JP Tower, The Tokyo Chamber of Commerce and Industry in Tokyo from March 21 (Fri) to 23 (Sun), 2014.

Kagoshima University Korimoto Campus in Kagoshima from March 16 (Sun) to 18 (Tues), 2014.

Tohoku University Kawauchi-Hagi Hall, Sendai International Center in Sendai from March 19 (Wed) to 21 (Fri), 2014.

The PhysioDesigner 1.0 beta6 has been relased. That  is now available from  http://physiodesigner.org/

The young workshop in HD Physiology for young researchers will be held at Loisir hotel TOOHASHI from Sep 28 (Sat) to 30 (Mon), 2013.

Please access this site about detailed information.

The PhysioDesigner 1.0 beta5 has been relased. That  is now available from  http://physiodesigner.org/

7th Plenary meeting of FY2013 was held on June. 27, 2013 at The university of Tokyo.

All principal investigators and collaborators joined in the meeting and discussed the research plan and management of this project.

An important original paper by Prof. Inoue group was published by J. Physiology.

Juan Shi, Naomi Geshi, Shinichi Takahashi, Shigeki Kiyonaka, Jun Ichikawa, Yaopeng Hu, Yasuo Mori, Yushi Ito and Ryuji Inoue.

Molecular determinants for cardiovascular TRPC6 channel regulation by Ca²⁺/calmodulin-dependent kinase II

Published online before print March 25, 2013, doi: 10.1113/jphysiol.2013.251249

The PhysioDesigner 1.0 beta4 has been relased. That  is now available from  http://physiodesigner.org/

An important original paper by Prof. Ishikawa et al., was published by Circulation.

Lo Lai, PhD; Lin Yan, PhD; Shumin Gao, MD, PhD; Che-Lin Hu, PhD; Hui Ge, BS; Amy Davidow, PhD; Misun Park, PhD; Claudio Bravo, MD; Kousaku Iwatsubo, MD, PhD; Yoshihiro Ishikawa, MD; Johan Auwerx, MD, PhD; David A. Sinclair, PhD; Stephen F. Vatner, MD; Dorothy E. Vatner, MD

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

Published online before print March 27, 2013, doi: 10.1161/​CIRCULATIONAHA.112.001212

The 2nd HD Physiology international symposium will be held at  My Plaza Hall from June 28 (Fri) to 29 (Sat), 2013.

Please access the official site about detailed information.

An important original paper by Dr. Fujiwara et al., was published by J Physiol.

Yuichiro Fujiwara, Tatsuki Kurokawa, Kohei Takeshita, Atsushi Nakagawa, H. Peter Larsson and Yasushi Okamura.

Gating of the designed trimeric/tetrameric voltage-gated H⁺ channel. The Journal of Physiology. 591;627-640.

Addional Information is linked from the site of Physiological Society of Japan. (in japanese)

http://physiology.jp/exec/page/stopics84/

An important original paper by Dr. Ichida et al., was published by Nature Communications.

Kimiyoshi Ichida, Hirotaka Matsuo, Tappei Takada, Akiyoshi Nakayama, Keizo Murakami, Toru Shimizu, Yoshihide Yamanashi, Hiroshi Kasuga, Hiroshi Nakashima, Takahiro Nakamura, Yuzo Takada, Yusuke Kawamura, Hiroki Inoue, Chisa Okada, Yoshitaka Utsumi, Yuki Ikebuchi, Kousei Ito, Makiko Nakamura, Yoshihiko Shinohara, Makoto Hosoyamada, Yutaka Sakurai, Nariyoshi Shinomiya, Tatsuo Hosoya, Hiroshi Suzuki.

Decreased extra-renal urate excretion is a common cause of hyperuricemia.

6th Plenary meeting of FY2013 was held on Jan. 16-17, 2013 at Okinawa Institute of Science and Technology (OIST).

All principal investigators and collaborators joined in the meeting and discussed the research plan and management of this project.

Pacifico Yokohama in Yokohama  from March 15 (Fri) to 17 (Sun), 2013.

The PhysioDesigner 1.0 beta3, which is now available from here, has been released.

http://www.cinc2013.org/index.php

The  PhysioDesigner 1.0 beta2, which is now available from here.

Fukuoka International Congress Center in Fukuoka  from March 21 (Tue) to 23 (Sat), 2013.

The Tower Hall Funabori in Tokyo from March 27 (Wed) to 29 (Fri), 2013.

HD physiology project is going to exhibite its production and to demonstrate its new physiome platform software.

5th Plenary meeting of FY2012 was held on Jul. 22-24, 2012 at Fukuoka University.

All principal investigators and collaborators joined in the meeting and discussed the research plan and management of this project.

Prof. Kitano will talk as a keynote speaker.

Venue: IET London: Savoy Place

Date:  18 (Tue)–20(Thr) Sep 2012.

A first issue of News Letter was lunched on June 20th, 2012.

An important original paper by Prof. Makita et al., was published by Circulation: Arrhythmia and Electrophysiology.

Naomasa Makita, Akiko Seki, Naokata Sumitomo, Halina Chkourko, Shigetomo Fukuhara,  Hiroshi Watanabe, Wataru Shimizu, Connie R. Bezzina, Can Hasdemir, Hideo Mugishima, Takeru Makiyama, Alban Baruteau, Estelle Baron, Minoru Horie, Nobuhisa Hagiwara, Arthur A.M. Wilde, Vincent Probst, Hervé Le Marec, Dan M. Roden, Naoki Mochizuki, Jean-Jacques Schott, and Mario Delmar.

A Connexin40 Mutation Associated With a Malignant Variant of Progressive Familial Heart Block Type I

Published online before print January 13, 2012// Circulation: Arrhythmia and Electrophysiology. 2012; vol. 5 163-172 doi: 10.1161/​CIRCEP.111.967604v

4th Plenary meeting of FY 2012 together with 1st HDP international symposium was held on Jan. 19-20, 2012 at Tokyo University.

All principal investigators and collaborators joined in the meeting and discussed the research plan and management of this project.

The latest standard release of insilicoIDE 1.4.4, which is now available from here. The newly-uploaded version has solved some problems.

An important review papaer from Kitano group was published by Nature Review Genetic.

Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Hiroaki Kitano.

Software for systems biology: from tools to integrated platforms

Nature Reviews Genetic, advance online publication, Published online 3 November 2011

An important original paper by Dr. Nakajo et al., was published by Journal of General Physiology.

Koichi Nakajo, Atsuo Nishino, Yasushi Okamura, Yoshihiro Kubo.

KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue.

Published October 31, 2011// JGP vol. 138 no. 5 521-535.

An important original paper from Dr. Funahashi et al., was published by Frontiers in System Biology.

Hiroi N, Lu J, Iba K, Tabira A, Yamashita S, Okada Y, Flamm C, Oka K, Köhler G, Funahashi A.

Physiological environment induces quick response – slow exhaustion reactions.

Front Physiol. 2011;2:50. Epub 2011 Sep 21.

1st CellDesigner and PhysioDesigner tutorial was held on Aug. 20, 2011 at Keio University.

in-depth information from here (Notice: You will require a password to access that page.)

3rd Plenary meeting of FY2011 was held on Jun. 19-20, 2011 at Osaka University Nakanoshima Center.

All principal investigators and collaborators joined in the meeting and discussed the research plan and management of this project.

The 7th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS).

Taipei, Taiwan on September 11-14, 2011.

The deadline for early registration, abstract submission, and application for Young Investigator Award is APRIL 30, 2011.

Review Issue: System Biology

Journal of Physiology: March 1, 2011 589 (5)

Nature 468, 879 (2010) | doi:10.1038/468879a

Biologists join physicists in a bid to map the workings of the human organ at all scales.

2nd Plenary meeting of FY2011 was held on Feb. 21, 2011 at Osaka University Nakanoshima Center.

All principal investigators and collaborators joined in the meeting and discussed the research plan and management of this project.

This conference is a joint Conference with The 116th Annual Meeting of the Japanese Association of Anatomists. The subtitle is “Shaping the future of life sciences-towards structural and functional integration”.

The 27th Annual Meeting of the Japanese Society of Electrocardiology was held 8-9 October, 2010 in Oita.

HD Physiology.jp launched! The site provides information about this HD Physiology project and hot news and trends in the integrative life sciences.

Kick-off symposium on HD Physiology project was held on Sep. 25, 2010 at Osaka University Nakanoshima Center.

Dr Hiroaki Kitano gave an overview of our research project and expressed a commitment to realizing an integrative simulation linked cardiac electro-functions to systemic drug circulation, on a novel software platform.

1st Plenary meeting of FY2010 was held on Sep. 24, 2010 at Osaka University Nakanoshima Center.

All principal investigators and collaborators joined in the meeting and discussed the research plan and management of this project.

Cardiome subgroup meeting was held at Osaka University Medical School. Members confirmed to pursue collaboration within the subgroup

The Japan MEXT announced the annual call for research proposals on our project (FY2011-FY2012).  Please follow the guidelines and instructions when applying.

for detail

Platform technical meeting was held on Aug. 24th, 2010 at Sony CSL.

Project management committee meeting was held on Aug. 2nd, 2010 at Osaka University.  The mid-term management plan was agreed.

The research project of “Establishment of Integrative Multi-level Systems Biology and its Applications” has been adopted as a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan.  This is the five years project from FY2010 to FY2015.  With the use of mathematical model derived from the physiological theory or concept, we try to quantitatively describe the systems of function of life. Now we call our project “HD Physiology project”. HD primary means High-Definition, and it also means Human Disease or Hierarchically Designed. As for the details of this project, please refer the page of “About HD Physiology”.